ÖáÏòÁã²´ËɱȽṹÐÄѪ¹ÜÖ§¼ÜµÄÉè¼Æ¡¢3D´òÓ¡Óë±íÕ÷(2)
4.3.1. ÈýµãÍäÇú²âÊÔ
ÈýµãÍäÇúÊÔÑéÓÃÀ´¼ì²âÖ§¼ÜµÄÍäÇúÐÔÄÜ£¨Èá˳ÐÔ£©£¬Èá˳ÐԺõÄÖ§¼ÜÔÚÖ§¼Ü½éÈëÖÎÁƹý³ÌÖÐÄܹ»¸üÈÝÒ×ͨ¹ý¶¯ÂöÍäÇú²¿·Ö¡£Ö§¼ÜÈá˳ÐÔ´óСÓÃÍäÇú¸Õ¶ÈÀ´±íʾ£ºÍäÇú¸Õ¶ÈÔ½´ó£¬Ö§¼ÜÈá˳ÐÔԽС¡£ÍäÇú¸Õ¶Èͨ¹ýE¡¤ I ¼ÆË㣬¾ßÌå±íʾΪ[26,28]£º
ʽÖУ¬FΪÍâÍäÇúÁ¦£»LΪ֧¼Ü¿ç¶È£»fΪ֧¼ÜÍäÇúÄӶȡ£±¾ÊµÑéÖУ¬LΪ11 mm£¬Òò´Ë£¬µ±±äÐÎfÉèΪ¹Ì¶¨Öµ£¬¶ÔÓ¦¸üСÍâÁ¦FµÄÖ§¼Ü¾ßÓиüºÃµÄÖ§¼ÜÈá˳ÐÔ¡£µ±±äÐÎf Ϊ2 mmʱ£¬A¡¢B¡¢CÈý×éÖ§¼Ü¶ÔÓ¦µÄÍâÁ¦FÈçͼ9£¨d£©Ëùʾ£»B¡¢D¡¢EÈý×éÖ§¼Ü¶ÔÓ¦µÄÍâÁ¦FÈçͼ9£¨h£©Ëùʾ¡£
ÓÉͼ9£¨a£©~£¨d£©¿ÉÖª£¬A¡¢B¡¢CÈý×éÈá˳ÐÔ¹ØϵΪB1 < A1 ¡Ö C1¡¢A2 < B2 < C2ºÍA3<B3<C3£»Ëæ×ÅÁ¬½Ó¸Ë³¤¶È´Ó1.00 mmÔö¼Óµ½1.50 mm£¬¶Ô§¶2¡¢§¶3ºÍ§¶4Ö§¼Ü£¬¸÷×é¼äµÄC×éÓëA×éÖ§¼Ü£¨C1/A1, C2/A2, C3/A3£©ÍâÁ¦FÖ®±È·Ö±ðΪ1.01¡¢0.77¡¢0.49¡£ÓÉͼ9£¨e£©~£¨h£©¿ÉÖª£¬B¡¢D¡¢EÈý×éÈá˳ÐÔ¹ØϵΪE1 < B1 < D1¡¢E2 < B2 < D2¡¢E3 < B3 < D3¡£
ͼ9.²»Í¬½á¹¹ºÍÖÆÔì²ÎÊýµÄ3D´òÓ¡PCLÖ§¼ÜµÄÈýµãÍäÇú²âÊÔ½á¹û¡££¨a£©~£¨c£©Ö§¼ÜÁ¬½Ó¸Ë³¤¶È·Ö±ðΪ1 mm¡¢1.25 mmºÍ1.5 mmʱ£¨¶ÔÓ¦A¡¢B¡¢CÈý×飩£¬¸÷×éÖ§¼ÜÍâÁ¦FÓëÖ§¼Ü±äÐÎÇúÏßͼ£»£¨d£©µ±Ö§¼Ü±äÐÎΪ2 mmʱ£¬¸÷×éÖ§¼Ü¶ÔÓ¦µÄÍâÁ¦F´óС£»£¨e£©~£¨g£©ÂݸËÅçͷתËÙΪ8.4 r¡¤min−1 ¡¢11.2 r¡¤min−1 ºÍ14 r¡¤min−1 £¨¶ÔÓ¦D¡¢B¡¢EÈý×飩ʱ£¬¸÷×éÖ§¼ÜÍâÁ¦FÓëÖ§¼Ü±äÐÎÇúÏßͼ£»£¨h£©µ±Ö§¼Ü±äÐÎΪ2 mmʱ£¬¸÷×éÖ§¼Ü¶ÔÓ¦µÄÍâÁ¦F´óС¡£Í¼£¨d£©ºÍ£¨h£©ÖеÄÊý¾ÝÒÔƽ¾ùÖµ¡ÀÎó²î·½Ê½±íʾ¡£
© Engineering
±í3ËùʾΪ±äÐÎfΪ2 mmʱ£¬¸÷×éÖ§¼ÜµÄÍäÇú¸Õ¶ÈÖµ£¨Æ½¾ùÖµ£©¡£¾Ý±¨µÀ[29]£¬´ËÇ°ÉÌÒµ»¯µÄAbsorb GT1 Ö§¼ÜÍäÇú¸Õ¶ÈֵΪ4.20 N¡¤ mm2 £¬ÕâÓëA1¡¢C1¡¢C3¡¢ D1~D3µÈ¼¸×éÖ§¼ÜÍäÇú¸Õ¶ÈÖµ½Ó½ü¡£Òò´Ë£¬A1¡¢C1¡¢ C3¡¢D1~D3Ö§¼Ü¾ßÓÐÏà¶ÔºÏÊʵÄÍäÇúÈá˳ÐÔ¡£
±í3 3D´òÓ¡PCLÖ§¼ÜʵÑé¸÷×éÍäÇú¸Õ¶ÈÖµ
4.3.2. ¾¶ÏòѹËõ²âÊÔ
¾¶ÏòѹËõÊÔÑéÓÃÓÚÆÀ¹À¾¶ÏòÇ¿¶È£¬´Ó¶øÈ·¶¨Ö§¼ÜµÄ¾¶ÏòÖ§³ÅÁ¦¡£¾ßÓÐÁ¼ºÃ¾¶ÏòÇ¿¶ÈµÄÖ§¼Ü¿ÉÒÔÌṩ¸üºÃµÄÖ§³Å¡£¾¶ÏòÇ¿¶È¿ÉÒÔÓþ¶Ïò¸Õ¶È±íʾ£º¾¶Ïò¸Õ¶ÈÔ½´ó£¬¾¶ÏòÇ¿¶ÈԽС¡£SchmidtµÈ[30]Ìá³ö½«Ö§¼Ü¾¶Ïò¸Õ¶È¶¨ÒåΪ֧¼ÜÖ±¾¶´ÓÍâѹ0µ½Íâѹ0.2 bar (1 bar = 105 Pa)ʱµÄ±ä»¯³Ì¶È[ʽ£¨16£©]¡£ASTM±ê×¼F3067-14 [27]½¨ÒéʹÓÃ˲ʱ֧¼ÜÖ±¾¶À´¼ÆËãÖ§¼ÜѹËõ±È£¬¶ø·Ç½öÊÊÓóõʼֱ¾¶[ʽ£¨17£©¡¢£¨18£©]¡£Òò´Ë£¬¾¶Ïò¸Õ¶ÈÊǵ±×÷ÓÃÔÚÖ§¼ÜÉϵÄ˲ʱѹÁ¦Îª0.2 barʱµÄѹËõ±È¡£
Ö§¼Ü¾¶ÏòÇ¿¶ÈÖ÷ÒªÓëÖ§³Å¸Ë¿í¶ÈtÒÔ¼°ZÐλ·ÊýÄ¿Óйء£ÓÉͼ10£¨a£©~£¨d£©¿ÉÖª£¬A¡¢B¡¢CÈý×éÖ§¼Ü¾¶Ïò¸Õ¶È¹ØϵΪBi>Ci>Ai£¨i = 1, 2, 3£©£¬Òò´ËÈý×éÖ§¼Ü¾¶ÏòÇ¿¶È¹ØϵΪBi£¼Ci£¼Ai£¨i = 1, 2, 3£©£»ÓÉͼ10£¨e£©~£¨h£©¿ÉÖª£¬B¡¢D¡¢EÈý×éÖ§¼Ü¾¶Ïò¸Õ¶È¹ØϵΪDi>Bi>Ei£¨i = 1, 2, 3£©£¬Òò´ËÈý×éÖ§¼Ü¾¶ÏòÇ¿¶È¹ØϵΪDi£¼Bi£¼Ei (i = 1, 2, 3)¡£
¾Ý±¨µÀ[30]£¬ÉÌÒµ»¯Ö§¼Ü¾¶Ïò¸Õ¶È´Ó0.51%µ½ 3.99%£¬ÕâÓëA2¡¢A3¡¢C2¡¢C3¡¢E3Ö§¼ÜÏà½ü¡£Òò´Ë£¬ A2¡¢A3¡¢C2¡¢C3¡¢E3Ö§¼Ü¾ßÓÐÏà¶ÔºÏÊʵľ¶ÏòÇ¿¶È¡£
ͼ10.²»Í¬½á¹¹ºÍÖÆÔì²ÎÊýµÄ3D´òÓ¡PCLÖ§¼ÜµÄ¾¶ÏòÍäÇú²âÊÔ½á¹û¡££¨a£©~£¨c£©Ö§¼ÜÁ¬½Ó¸Ë³¤¶È·Ö±ðΪ1 mm¡¢1.25 mmºÍ1.5 mm£¨¶ÔÓ¦A¡¢B¡¢CÈý×飩ʱ£¬¸÷×éÖ§¼ÜÍâÁ¦FÓëÖ§¼ÜѹËõ±ÈÇúÏßͼ£»£¨d£©£¨a£©~£¨c£©Öи÷×éÖ§¼Ü¾¶Ïò¸Õ¶È´óС£»£¨e£©~£¨g£©ÂݸËÅçͷתËÙΪ8.4 r¡¤min−1 ¡¢11.2 r¡¤min−1 ºÍ14 r¡¤min−1 £¨¶ÔÓ¦D¡¢B¡¢EÈý×飩ʱ£¬¸÷×éÖ§¼ÜÍâÁ¦FÓëÖ§¼ÜѹËõ±ÈÇúÏßͼ£»£¨h£©£¨e£©~£¨g£©Öи÷×éÖ§¼Ü¾¶Ïò¸Õ¶È´óС¡££¨d£©ºÍ£¨h£©ÖеÄÊý¾ÝÒÔƽ¾ùÖµ¡ÀÎó²î±íʾ¡£
© Engineering
4.3.3. ¾¶ÏòÀ©ÕŲâÊÔ
¾¶ÏòÀ©ÕŲâÊÔÖУ¬C1¡¢C2×éÖ§¼Ü¾ù·Ö±ðÅòÕÍÖÁÀ©ÕűÈΪ10%¡¢20%¡£¼´C1×éÖ§¼ÜÓÉÖ±¾¶2 mm·Ö±ðÀ©ÕÅÖÁ2.2 mm¡¢2.4 mm£¬C2×éÖ§¼ÜÓÉÖ±¾¶3 mm·Ö±ðÀ©ÕÅÖÁ 3.3 mm¡¢3.6 mm£¬·Ö±ð²âÁ¿Ö§¼Ü³¤¶È£»Ëæºó£¬È¥³ýÀ©ÕÅÁ¦£¬¹Û²ìÖ§¼Ü¾¶Ïò»Øµ¯£¬²¢¼Ç¼֧¼Ü´ËʱµÄ³¤¶È¡£Ö§¼Ü³õʼֱ¾¶O§¶¡¢À©ÕÅ×î´óÖ±¾¶M§¶ÒÔ¼°»Øµ¯ºóÖ±¾¶R§¶Èçͼ 11£¨a£©Ëùʾ¡£Ö§¼ÜÖ±¾¶»ØËõ±È¼ÆËãÈçÏ£º
C1Ö§¼ÜÔÚÀ©ÕÅÖÁ110%ºÍ120%ʱ£¬Ö§¼ÜÖ±¾¶»Øµ¯·Ö±ðΪ69%ºÍ41%£»C2Ö§¼ÜÔÚÀ©ÕÅÖÁ110%ºÍ120%ʱ£¬Ö§¼ÜÖ±¾¶»Øµ¯·Ö±ðΪ77%ºÍ71%¡£3D´òÓ¡PCLÖ§¼ÜµÄ¾¶Ïò»ØËõ³Ì¶È½Ï´ó£¬ÕâÓëPCLÖ§¼ÜÁ¼ºÃµÄµ¯ÐÔÓйء£Îª½â¾ö´ËÎÊÌ⣬δÀ´µÄÑо¿½«Ì½Ë÷ÆäËûÉúÎï²ÄÁÏ¡£
Ö§¼Ü³õʼ³¤¶ÈOL¡¢À©ÕÅ×î´ó³¤¶ÈMLÒÔ¼°»Øµ¯ºó³¤¶ÈRLÈçͼ11£¨b£©Ëùʾ¡£Ö§¼ÜÖáÏò»ØËõ±È¼ÆËãÈçÏ£º
C1Ö§¼ÜÔÚÀ©ÕÅÖÁ110%ºÍ120%ʱ£¬Ö§¼Ü¾¶Ïò»Øµ¯·Ö±ðΪ0.33%ºÍ0.13%£»C2Ö§¼ÜÔÚÀ©ÕÅÖÁ110%ºÍ120%ʱ£¬Ö§¼ÜÖ±¾¶»Øµ¯·Ö±ðΪ0.40%ºÍ0.09%¡£×÷Ϊ¶Ô±È£¬Ä¿Ç°ÉÌÒµ»¯Ö§¼ÜÖáÏò»ØËõÔÚ3%~5% [31]¡£Òò´Ë£¬¿ÉÒÔÈ·¶¨±¾Ñо¿ÖÐËùʹÓõÄÖ§¼ÜÉè¼Æ¾ßÓÐÏà¶ÔÎȶ¨¿É¿¿µÄÖáÏò³¤¶ÈÎȶ¨ÐÔ¡£
ͼ11. ¾¶ÏòÀ©ÕŽá¹û¡££¨a£©Ö§¼ÜÖ±¾¶±ä»¯£»£¨b£©Ö§¼Ü³¤¶È±ä»¯¡£ËùÓÐÊý¾ÝÒÔƽ¾ùÖµ¡ÀÎó²î±íʾ¡£
© Engineering
4.4. Ö§¼ÜÉúÎïÏàÈÝÐÔ
3D´òÓ¡PCLÖ§¼ÜÈÜѪ·ÖÎöʵÑé°´ÕÕASTM±ê×¼ F756-17¿ªÕ¹[32]£¬ÐÂÏÊÈËѪÓɱ±¾©»ªÐÅÒ½Ôº/Ç廪´óѧµÚÒ»¸½ÊôÒ½ÔººÏ·¨Ìṩ¡£ÈçÇ°±¨µÀ[33]£¬ÑùÆ·ÈÜѪÂÊͨ¹ý²âÁ¿Ñªºìµ°°×ÊÍ·ÅÁ¿À´È·¶¨£¬¿É±íʾΪ£º
ʽÖУ¬ODt´ú±íʵÑé×éÎü¹â¶È£»ODpºÍODn·Ö±ð±íʾÑôÐÔ×éºÍÒõÐÔ×éÎü¹â¶ÈÖµ¡£¸ù¾ÝASTM±ê×¼F756-17[32]£¬²ÄÁÏÈÜѪÂÊ¿É·Ö¼¶Îª·ÇÈÜѪ£¨0~2%£©¡¢Çá΢ÈÜѪ£¨2%~5%£©¡¢ÈÜѪ£¨>5%£©¡£3D´òÓ¡PCLÖ§¼ÜÈÜѪÂÊΪ 0.07% ¡À 0.02%£¨·ÇÈÜѪ£©¡£
3D´òÓ¡PCLÖ§¼Üϸ°ûÏàÈÝÐÔʵÑé°´ÕÕISO±ê×¼ 10993¨C5:2009¿ªÕ¹[34]£¬Ê¹ÓÃEGM-2 (endothelial cell growth medium-2)ÅàÑø»ù£¨ÈðÊ¿Lonza¹«Ë¾£¬»õºÅ cc3162£©ÅàÑøÈËÆê¾²ÂöÄÚƤϸ°û£¨HUVECs£¬ÃÀ¹ú ATCCϸ°û¿â£©£¬½«Ö§¼ÜÔÚ37 ¡æÅàÑø»ùÖзõÓý24 hÌáÈ¡²ÄÁϽþÌáÒº¡£½«HUVECsÔÚ37¡æ¡¢5% CO2¡¢½þÅÝÖ§¼Ü 24 hºóµÄEGM-2ÅàÑø»ùÖÐÅàÑø96 hºó£¬¼ÓÈëCCK-8£¨cell counting kit-8£¬ÈÕ±¾Dojindo¹«Ë¾£©·õÓý4 hºó£¬Ê¹ÓÃø±êÒDzâÁ¿Ï¸°û»îÐÔ£¬¼ÆË㹫ʽΪ£º
ʽÖУ¬ODt´ú±íʵÑé×éÎü¹â¶È£»ODpºÍODn·Ö±ð±íʾÑôÐÔ×éºÍÒõÐÔ×éÎü¹â¶ÈÖµ¡£¸ù¾Ýϸ°û»îÐÔÖµ£¬²ÄÁϵÄϸ°û¶¾ÐÔ¿É·ÖΪ0¼¶£¨¡Ý 100%£©¡¢1¼¶£¨80%~99%£©¡¢2¼¶£¨50%~79%£©¡¢3¼¶£¨30%~49%£©ºÍ4¼¶£¨0~29%£©¡£µ±²ÄÁÏϸ°û¶¾ÐÔ´óÓÚ2¼¶Ê±£¬ÈÏΪÆä¾ßÓÐϸ°û¶¾ÐÔ¡£3D´òÓ¡ PCLÖ§¼Üϸ°û»îÐÔΪ90% ¡À 5%£¨1¼¶£©£¬Òò´Ë£¬¿ÉÒÔÓÃÓÚϸ°ûʵÑé¡£
×ÛÉÏ£¬3D´òÓ¡PCLÖ§¼Ü¾ßÓÐÁ¼ºÃµÄÉúÎïÏàÈÝÐÔ¡£
5.1. ³ÉÐͲÎÊý¶Ô´òÓ¡ÄÜÁ¦Óë½á¹¹³ÉÐ͵ÄÓ°Ïì
5.1.1. ÅçÍ·¼ÓÈÈζÈ
Ö§¼ÜÖƱ¸Ç°£¬Í¨¹ýPCLµ¥Ë¿¼·³öÊÔÑéÑо¿ÁËÂݸ˼·³öÅçÍ·¼ÓÈÈζȶÔPCLË¿³ß´çÎȶ¨ÐÔºÍÇ¿¶ÈµÄÓ°Ï죬Ñо¿µÃÖªÔÚ80 ¡æºÍ82.5 ¡æʱPCLË¿¾ßÓиüºÃµÄ³ß´çÎȶ¨ÐÔ[ͼ4£¨c£©]£¬ÔÚ75 ¡æºÍ80 ¡æÏÔʾ¸üºÃµÄÀÉìÇ¿¶È¡£Òò´Ë£¬×ۺϿ¼Âǵ½²ÄÁϳÉÐÍÇ¿¶ÈºÍ³ß´çÎȶ¨ÐÔ£¬½«Âݸ˼·³öÅçÍ·¼ÓÈÈζÈÉ趨Ϊ80 ¡æÓÃÓÚÖ§¼ÜÖƱ¸¡£Èçͼ4 £¨b£©¡¢£¨d£©Ëùʾ£¬ÔÚ80 ¡æϼ·³öµÄPCLË¿¾ßÓÐÁ¼ºÃµÄ±íÃæÐÎò¡£
5.1.2. x-y-z Ô˶¯Ëٶȡ¢ÐýתÖáת¶¯ËÙ¶È
Èç±í1Ëùʾ£¬¿Éͨ¹ýµ÷½Úƽ̨Òƶ¯ËÙ¶ÈVRxºÍÂݸËÅçͷתËÙn¸Ä±äÖ§¼ÜË¿¿í£¨Ö§³Å¸Ë¿í¶È£©¡£ËæVRxÔö¼Ó£¬Ö§¼ÜË¿¿í¼õСÇÒ´òÓ¡Îȶ¨ÐÔϽµ£¨Îó²îϵÊýÔö´ó£©£»ËæÂݸËÅçͷתËÙnÔö¼Ó£¬Ö§¼ÜË¿¿íÔö´ó¶ø´òÓ¡Îȶ¨ÐÔÌáÉý£¨Îó²îϵÊý¼õС£©¡£Òò´Ë£¬×ۺϿ¼ÂÇ´òÓ¡Îȶ¨ÐÔ£¨ÈçÎó²îϵÊýСÓÚ10%£©Óë´òӡЧÂÊ£¬½«VRxÉèΪ1 mm¡¤ s−1 £¬Ë¿¿íͨ¹ý¸Ä±äÂݸËתËÙnµ÷½Ú¡£ÏàÓ¦µØ£¬xÖáÒƶ¯ËÙ¶ÈVxΪ ͼƬ mm¡¤ s−1 (0.866 mm¡¤ s−1 )£¬ÐýתÖáת¶¯ÏßËÙ¶ÈVRΪ 0.5 mm¡¤ s−1 £¨ÐýתÖáתËÙ¿Éͨ¹ýnm = VR¡Á60/¦Ð§¶¼ÆË㣬nm = 30/¦Ð§¶£¬µ¥Î»£ºr¡¤min−1 £¬§¶ÎªÖ§¼ÜÖ±¾¶£©¡£
5.1.3. Âݸ˼·³öËÙ¶È
ÔÚÖƱ¸²»Í¬²ÎÊý×éÖ§¼Üʱ£¬ÂݸËÅçͷתËÙn·Ö±ðÉèΪ8.4 r¡¤ min−1 £¨D×飩¡¢11.2 r¡¤ min−1 £¨A¡¢B¡¢C ×飩¡¢14 r¡¤ min−1 £¨E×飩¡£Èçͼ7Ëùʾ£¬Ö§¼ÜË¿¿ítÓëÂݸËתËÙn³ÊÕýÏà¹Ø£ºËæÂݸËתËÙÔö¼Ó£¬Ö§¼ÜË¿¿íÔö´ó£¨D£¼A=B=C£¼E£©¡£A¡¢B¡¢CÈý×éÖ§¼Ü²ÉÓÃÏàͬתËÙÖƱ¸£¬µ«ÊÇ£¬ÓëA¡¢B×éÖ§¼ÜÏà±È£¬C×éÖ§¼Ü¾ßÓÐÏà¶Ô½Ï´óµÄÖ§¼ÜË¿¿í¡£Òò´Ë£¬ÔÚδÀ´µÄÑо¿ÖÐÐèÒª½øÒ»²½Ìá¸ßÖ§¼ÜÖÆÔìµÄÎȶ¨ÐÔ¡£
5.2. ½á¹¹²ÎÊý¶Ô 3D ´òÓ¡ PCL Ö§¼Ü»úеÐÔÄÜÓ°Ïì
֮ǰÒÑÓÐÑо¿Ê¹ÓÃÁ˸÷ÖÖ·½·¨¼ì²âÖ§¼ÜµÄ»úеÐÔÄÜ£¬ÍäÇúÈá˳ÐԺ;¶ÏòÇ¿¶ÈÊÇÖ§¼Ü»úеÐÔÄܵÄÁ½¸öÖØÒªÖ¸±ê£¬ÓëÖ§¼ÜµÄ¼¸ºÎ²ÎÊýÃÜÇÐÏà¹Ø[14,28]¡£»ùÓÚ4.3.1½ÚºÍ4.3.2½ÚµÄÌÖÂÛ¿ÉÖª£¬ÍäÇúÈá˳ÐÔ¿ÉÓÃÍäÇú¸Õ¶È±íʾ£¬½Ï¸ßµÄÍäÇú¸Õ¶È±íÃ÷Ö§¼Ü½ÏµÍµÄÈáÈÍÐÔ£»¾¶ÏòÇ¿¶È¿ÉÓþ¶Ïò¸Õ¶È±íʾ£¬½Ï¸ßµÄ¾¶Ïò¸Õ¶È±íÃ÷½ÏµÍµÄ¾¶ÏòÇ¿¶È¡£ÔÚ±¾Ñо¿ÖУ¬Ó°ÏìÖ§¼Ü»úеÐÔÄܵÄÖ÷Òª²ÎÊýÊÇÁ¬½Ó¸ËµÄ³¤¶ÈhºÍÖ§¼ÜË¿¿ít¡£
5.2.1. Á¬½Ó¸Ë³¤¶È
A¡¢B¡¢CÈý×éÖ§¼Ü¶ÔÓ¦Á¬½Ó¸Ë³¤¶Èh·Ö±ðΪ1 mm¡¢ 1.25 mmºÍ1.5 mm£¬¶øÖ§¼Ü³¤¶È¹Ì¶¨£¨18 mm£©£¬Òò´ËËæ×ÅÁ¬½Ó¸Ë³¤¶ÈhÔö¼Ó£¬Ö§¼Ü¾ßÓиüÉÙµÄZÐλ·£¬Ö§¼ÜÍäÇúÐÔÄÜËæÖ®Ôö¼Ó¶ø¾¶ÏòÇ¿¶ÈϽµ¡£Òò´Ë£¬ÀíÏëµÄÖ§¼ÜÍäÇúÐÔÄܺ;¶ÏòÇ¿¶È½á¹ûӦΪ£ºAi£¼Bi£¼Ci¡¢Ci£¼Bi£¼Ai (i =1, 2, 3)¡£
ÓÉͼ9£¨a£©~£¨d£©ºÍ±í3¿ÉÖª£¬A¡¢B¡¢CÈý×éÍäÇúÐÔÄܶԱÈΪ£ºB1£¼A1¡ÖC1¡¢A2£¼B2£¼C2¡¢A3£¼B3£¼C3¡£×ÜÌå¶øÑÔ£¬Ëæ×ÅÁ¬½Ó¸Ë³¤¶ÈhÔö¼Ó£¬Ö§¼ÜÍäÇúÐÔÄÜÌá¸ß£¬ÔÚÖ§¼ÜÖ±¾¶½Ï´óʱ±íÏÖ¸ü¼ÓÃ÷ÏÔ¡£ÓÉͼ10£¨a£©~£¨d£©¿ÉÖª£¬A¡¢B¡¢CÈý×éÖ§¼Ü¾¶ÏòÇ¿¶È£ºBi£¼Ci£¼Ai (i =1, 2, 3)£¬ÕâÓëÀíÏë½á¹ûÓÐËùÆ«²î£¬ÔÚ5.2.2½ÚÖлá½øÒ»²½½âÊÍ´ËÏÖÏó¡£
×ÜÖ®£¬¾ßÓиü³¤Á¬½Ó¸ËµÄÖ§¼ÜÔÚÈá˳ÐÔÉϾßÓÐÓÅÊÆ¡£µ«ÊÇ£¬ÔÚÕâÒ»²¿·Ö²¢²»È·¶¨³¤Á¬½Ó¸Ë£¨ÔÚÖ§¼ÜË¿¿íÂÔ΢´æÔÚÇø±ðµÄÇé¿öÏ£©ÊÇ·ñÑϸñ²»ÀûÓÚ¾¶ÏòÇ¿¶È¡£
5.2.2. Ö§¼ÜË¿¿í
D¡¢B¡¢EÈý×éÖ§¼Ü¶ÔÓ¦ÂݸËÅçͷתËÙt·Ö±ðΪ 8.4 r¡¤min−1 ¡¢11.2 r¡¤min−1 ¡¢14 r¡¤min−1 £¬Ö§¼ÜË¿¿íÓëÂݸËתËÙÕýÏà¹Ø£¬Ëæ×ÅתËÙÔö¼Ó£¬Ö§¼ÜË¿¿íÔö´ó£¬ËæÖ®µ¼Ö¸ü´óµÄ¾¶ÏòÇ¿¶ÈºÍ¸üµÍµÄÍäÇúÈá˳ÐÔ¡£Òò´Ë£¬D¡¢B¡¢EÈý×éÖ§¼Ü¶Ô±ÈµÄÀíÏë½á¹ûΪ£ºÈá˳ÐÔEi£¼Bi£¼Di£¬¾¶ÏòÇ¿¶È Di£¼Bi£¼Ei£¨i = 1, 2, 3£©¡£
ÓÉͼ7¡¢Í¼9¡¢Í¼10¿ÉÖª£¬Êµ¼Ê²âÊÔ½á¹ûÓëÉÏÊöÀíÏë½á¹ûÒ»Ö£¬Òò´Ë£¬¿ÉµÃÖ§¼ÜË¿¿íÊÇÖ§¼Ü¾¶ÏòÇ¿¶ÈµÄÖ÷ÒªÒòËØ¡£´ËÍ⣬5.2.1½ÚÖÐÌáµ½£¬A¡¢B¡¢CÈý×éÖ§¼Ü¾¶ÏòÇ¿¶ÈBi£¼Ci£¼Ai (i =1, 2, 3)£¬ÕâÓëÀíÏë½á¹ûCi£¼Bi£¼Ai ²»Ò»Ö¡£¸Ã½á¹û¿ÉÒÔͨ¹ýÖ§¼ÜË¿¿í½âÊÍ£º´Óͼ7£¨f£©¿ÉÒÔÈ·¶¨£¬¾¡¹ÜC×éÖ§¼Ü¾ßÓиüÉÙµÄZÐλ·£¬µ«ÓÉÓÚÆäË¿¿í¸ü´ó£¬ÓëB×éÏà±È£¬Æ侶ÏòÇ¿¶È¸ü´ó¡£Õâ½øÒ»²½Ö¤Ã÷ÁËÖ§¼ÜË¿¿íÊǾö¶¨Ö§¼Ü¾¶ÏòÇ¿¶ÈµÄÖ÷µ¼ÒòËØ¡£
5.2.3. С½á
¸ù¾Ý5.2.1½ÚºÍµÚ5.2.2½ÚµÄÌÖÂÛ£¬¿ÉÒÔ¿´³öÖ§¼ÜÈá˳ÐԺ;¶ÏòÇ¿¶ÈÊÇÒ»¶ÔÏ໥ì¶ÜµÄÐÔÄÜ¡£ÕâÊÇΪʵÏÖÖ§¼Ü×ۺϻúеÐÔÄܶøÐèȨºâÖ§¼Ü½á¹¹²ÎÊýµÄ½á¹û¡£¶ÔÓÚÏàֱͬ¾¶µÄÖ§¼Ü£¬Ö§¼ÜµÄ»úеÐÔÄÜ£¨ÍäÇúÈá˳ÐԺ;¶ÏòÇ¿¶È£©ÓëÁ¬½Ó¸Ë³¤¶ÈºÍÖ§¼ÜË¿¿íÃÜÇÐÏà¹Ø¡£
Ö§¼ÜÍäÇúÈá˳ÐÔ¡£×ÛÉÏ¿ÉÖª£¬¾ßÓнϳ¤Á¬½Ó¸ËºÍ½ÏС˿¿íµÄÏàֱͬ¾¶Ö§¼ÜÇãÏòÓÚ¾ßÓиüºÃµÄÍäÇúÈá˳ÐÔ¡£Òò´Ë£¬¾ßÓÐËÉÉ¢¼¸ºÎ½á¹¹µÄÖ§¼ÜÇãÏòÓÚ±íÏÖ³ö¸üºÃµÄÈá˳ÐÔ¡£
¾¶ÏòÇ¿¶È¡£½áºÏÉÏÊöÌÖÂÛ£¬¿ÉÒÔÍƶϳöÖ§¼ÜË¿¿í£¨t£©ÊÇÓ°ÏìÖ§¼Ü¾¶ÏòÇ¿¶ÈµÄÖ÷ÒªÒòËØ£¬Õâ¿ÉÒÔ½áºÏʽ£¨12£©µÃµ½ÑéÖ¤¡£Ê½£¨12£©±íÃ÷Ö§¼ÜµÄ½á¹¹Ç¿¶ÈÓët3 ³ÉÕý±È£¬Óëh³É·´±È¡£ÕâÒâζ×ÅÖ§¼ÜµÄ¾¶ÏòÇ¿¶È¸üÒ×Êܵ½tµÄÓ°Ïì¡£¿ÉÒÔÍƶϣ¬¾ßÓнϴóÁ¬½Ó¸Ë£¨h£©ºÍÊÊÖÐÖ§¼ÜË¿¿íµÄÖ§¼Ü¸üÓÐÀûÓÚÔÚÈá˳ÐÔÓ뾶ÏòÇ¿¶ÈÖ®¼äÈ¡µÃƽºâ¡£
±¾Ñо¿ÖУ¬Ñо¿ÈËÔ±¿ª·¢ÁËÒ»ÖÖÐÂÐÍ»ùÓÚ΢Âݸ˼·³öʽ 3D´òӡϵͳ£¬Í¨¹ýÔö¼ÓµÚËÄÖáÐýתÖáÖÆÔìÖ§¼Ü¡£Ñо¿Ìá³öÁËÒ»ÖÖÐÂÐÍZPR½á¹¹ÐÄѪ¹ÜÖ§¼Ü£¬²¢Ö¤Ã÷ÁËÖ§¼ÜÀ©Õźó¿É±£³ÖÖáÏò³¤¶ÈÎȶ¨¡£Í¨¹ýµ¥Ë¿ÊµÑé³õ²½Ñо¿ÁËÊʺÏÖ§¼ÜÖƱ¸µÄ³ÉÐͲÎÊý£¬Ëæºó²ÉÓá°ÖغϴòÓ¡·¨¡±ÖƱ¸¾ßÓв»Í¬²ÄÁÏ£¨PLLA¡¢PCL£©¡¢ÐÎ×´¡¢¼¸ºÎ½á¹¹µÄÖ§¼Ü£¬½øÒ»²½Ñо¿Á˲»Í¬²ÎÊý³ÉÐÍPCLÖ§¼ÜµÄ»úеÐÔÄÜ¡£
×ÛÉÏ£¬±¾ÎÄÌá³öµÄ»ùÓÚ΢Âݸ˼·³öµÄ3D´òӡϵͳÏÔʾ³ö¸öÐÔ»¯ÖƱ¸Ö§¼ÜµÄDZÁ¦¡£È»¶ø£¬PCLÖ§¼ÜÈá˳ÐԵIJ»×ã±íÃ÷ÔÚδÀ´µÄÑо¿ÖÐÐè½øÒ»²½¸Ä½øÖ§¼ÜÉè¼Æ¡£´ËÍ⣬Óë½ðÊôÖ§¼ÜÏà±È£¬PCLÖ§¼ÜÔÚ¾¶ÏòÇ¿¶ÈºÍ¾¶Ïò»Øµ¯·½Ãæ²¢²»ÀíÏ룬֮ºó»¹Ðè̽Ë÷ÖƱ¸PLLA»ò¾ßÓиü¸ßÇ¿¶ÈºÍ¸üµÍÉ쳤ÂʵĿɽµ½â¾ÛºÏÎïÖ§¼Ü¡£
²Î¿¼ÎÄÏ×
[1] Stettler C, Wandel S, Allemann S, Kastrati A, Morice MC, Schömig A, et al. Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 2007;370:937¨C48.
[2] Zhang Y, Bourantas CV, Farooq V, Muramatsu T, Diletti R, Onuma Y, et al. Bioresorbable scaffolds in the treatment of coronary artery disease. Med Devices Evid Res 2013;6:37¨C48.
[3] Wiebe J, Nef HM, Hamm CW. Current status of bioresorbable scaffolds in the treatment of coronary artery disease. J Am Coll Cardiol 2014;64:2541¨C51.
[4] Ang HY, Bulluck H, Wong P, Venkatraman SS, Huang Y, Foin N. Bioresorbable stents: current and upcoming bioresorbable technologies. Int J Cardiol 2017;228:931¨C9.
[5] Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193¨C202.
[6] Onuma Y, Ormiston J, Serruys PW. Bioresorbable scaffold technologies. Circ J 2011;75:509¨C20.
[7] Iqbal J, Onuma Y, Ormiston J, Abizaid A, Waksman R, Serruys P. Bioresorbable scaffolds: rationale, current status, challenges, and future. Eur Heart J 2014;35:765¨C76.
[8] Stepak B, Anton´ czak AJ, Bartkowiak-Jowsa M, Filipiak J, Pezowicz C, Abramski KM. Fabrication of a polymer-based biodegradable stent using a CO2 laser. Arch Civ Mech Eng 2014;14:317¨C26.
[9] Guerra AJ, Farjas J, Ciurana J. Fibre laser cutting of polycaprolactone sheet for stents manufacturing: a feasibility study. Opt Laser Technol 2017;95:113¨C23.
[10] Guerra AJ, Ciurana J. 3D-printed bioabsordable polycaprolactone stent: the effect of process parameters on its physical features. Mater Des 2018;137:430¨C7.
[11] Martinez AW, Chaikof EL. Microfabrication and nanotechnology in stent design. WIREs Nanomed Nanobiotechnol 2011;3:256¨C68.
[12] Kaesemeyer WH, Sprankle KG, Kremsky JN, Lau W, Helmus MN, Ghatnekar GS. Bioresorbable polystatin fourth-generation stents. Coron Artery Dis 2013;24:516¨C21.
[13] Park SA, Lee SJ, Lim KS, Bae IH, Lee JH, Kim WD, et al. In vivo evaluation and characterization of a bio-absorbable drug-coated stent fabricated using a 3Dprinting system. Mater Lett 2015;141:355¨C8.
[14] Wu Z, Zhao J, Wu W, Wang P, Wang B, Li G, et al. Radial compressive property and the proof-of-concept study for realizing self-expansion of 3D printing polylactic acid vascular stents with negative poisson¡¯s ratio structure. Materials 2018;11(8):1357.
[15] Wang WQ, Liang DK, Yang DZ, Qi M. Analysis of the transient expansion behavior and design optimization of coronary stents by finite element method. J Biomech 2006;39:21¨C32.
[16] Stoeckel D, Bonsignore C, Duda S. A survey of stent designs. Minim Invasive Ther Allied Technol 2002;11:137¨C47.
[17] Attard D, Grima JN. Modelling of hexagonal honeycombs exhibiting zero Poisson¡¯s ratio. Phys Status Solidi Basic Res 2011;248:52¨C9.
[18] Masters IG, Evans KE. Models for the elastic deformation of honeycombs. Compos Struct 1996;35:403¨C22.
[19] Young WC, Budynas RG. Roark¡¯s formulas for stress and strain. 7th ed. Beijing: Tsinghua University Press; 2003. Chinese.
[20] Grima JN, Oliveri L, Attard D, Ellul B, Gatt R, Cicala G, et al. Hexagonal honeycombs with zero Poisson¡¯s ratios and enhanced stiffness. Adv Eng Mater 2010;12:855¨C62.
[21] Venkataraman N, Rangarajan S, Matthewson MJ, Harper B, Safari A, Danforth SC, et al. Feedstock material property¡ªprocess relationships in fused deposition of ceramics (FDC). Rapid Prototyp J 2000;6:244¨C52.
[22] Liu B, Xie Y, Wu M. Research on the micro-extrusion characteristic of mini-screw in the screw extruding spray head. Polym Bull 2010;64: 727¨C38.
[23] Wang F, Shor L, Darling A, Khalil S, Sun W, G¨¹çeri S, et al. Precision extruding deposition and characterization of cellular poly-e-caprolactone tissue scaffolds. Rapid Prototyp J 2004;10:42¨C9.
[24] Capone C, Di Landro L, Inzoli F, Penco M, Sartore L. Thermal and mechanical degradation during polymer extrusion processing. Polym Eng Sci 2007;47:1813¨C9.
[25] Liu C, Li Y, Zhang L, Mi S, Xu Y, Sun W. Development of a novel lowtemperature deposition machine using screw extrusion to fabricate poly(Llactide-co-glycolide) acid scaffolds. Proc Inst Mech Eng Part H J Eng Med 2014;228:593¨C606.
[26] F2606-08 Standard guide for three-point bending of balloon expandable vascular stents and stent systems. US Standard. West Conshohocken: American Society of Testing Materials; 2014.
[27] F3067-14 Guide for radial loading of balloon expandable and self expanding vascular stents. US Standard. West Conshohocken: American Society of Testing Materials; 2014.
[28] Wang Q, Fang G, Zhao Y, Wang G, Cai T. Computational and experimental investigation into mechanical performances of poly-L-lactide acid (PLLA) coronary stents. J Mech Behav Biomed Mater 2017;65:415¨C27.
[29] Schmidt W, Behrens P, Brandt-Wunderlich C, Siewert S, Grabow N, Schmitz KP. In vitro performance investigation of bioresorbable scaffolds¡ªstandard tests for vascular stents and beyond. Cardiovasc Revascularization Med 2016;17:375¨C83.
[30] Schmidt W, Lanzer P, Behrens P, Topoleski LDT, Schmitz KP. A comparison of the mechanical performance characteristics of seven drug-eluting stent systems. Catheter Cardiovasc Interv 2009;73:350¨C60.
[31] Colombo A, Stankovic G, Moses JW. Selection of coronary stents. J Am Coll Cardiol 2002;40:1021¨C33.
[32] F756-17 Standard practice for assessment of hemolytic properties of materials. US Standard. West Conshohocken: American Society of Testing Materials; 2017.
[33] Im SH, Kim CY, Jung Y, Jang Y, Kim SH. Biodegradable vascular stents with high tensile and compressive strength: a novel strategy for applying monofilaments via solid-state drawing and shaped-annealing processes. Biomater Sci 2017;5:422¨C31.
[34] ISO 10993-5:2009 Biological evaluation of medical devices¡ªpart 5: tests for in vitro cytotoxicity. EN Standard. Geneva: International Organization for Standardization; 2009.
(ÔðÈα༣ºadmin)
ÏÂһƪ£º¹ã¶«Ê¡¿ÆѧԺÖÇÄÜÖÆÔìÑо¿Ëù̼ÄÉÃ×¹ÜÔöÇ¿¼¤¹âÈÛ¸²¸ßìغϽðÍ¿²ã¼¼Êõ»ñ½øÕ¹
- Conflux Technology Ȗ110
- ͨÓÃÆû³µÏòForge NanoͶ×Ê
- »ªÖпƼ¼´óѧ£ºÔö²ÄÖÆÔìSi
- ¸³ÄÜÆû³µ¡¢Ò½ÁƵÈÐÐÒµ£üTP
- AmnovisÀûÓÃ3D´òÓ¡¼¼ÊõÖÆ
- ¹ú²úÁ¬ÐøÏËά3D´òÓ¡¿ªÍØ
- ¡¤È«3D´òÓ¡¼¼Êõ+¿É½µ½â¹¦ÄÜ£¬ÎÞÐè°ëµ¼Ìå
- ¡¤¾ÞÐÍ3D´òÓ¡»ú¿É¿ìËÙ½¨Ôì̼ÏËάÖÐ×Ó»ð¼ý
- ¡¤Öйú½¨ÖþµÚ¶þ¹¤³Ì¾ÖÈ¡µÃÒìÐͽ¨ÖþÓë²»¹æ
- ¡¤¡°Ò»É½ÆñÄÜÈݶþ»¢£¬¹ÚÃáÌûÊÈ«Çò²¥¡±´ò
- ¡¤¡°ÇàɽÂÌË®¡±´òÒ»×î¼ÑÉúФ£¬´ÊÓï½âÊÍÂä
- ¡¤¡°Ð¡¼ÒÐ׶ñѵ¶ùÀÉ£¬´ó¼ÒÀñÒå½Ì×ӵܡ±´ò
- ¡¤¡°³éÏó»×÷¡±´òÒ»×î¼ÑÉúФ£¬´ÊÓï½âÊÍÂä
- ¡¤¡°ÎŹýÔòϲ¡±ÊÇʲôÉúФ£¬´ÊÓï½âÊÍÂäʵ
- ¡¤È«3D´òÓ¡¼¼Êõ+¿É½µ½â¹¦ÄÜ£¬ÎÞÐè°ëµ¼Ìå
- ¡¤¾ÞÐÍ3D´òÓ¡»ú¿É¿ìËÙ½¨Ôì̼ÏËάÖÐ×Ó»ð¼ý
- ¡¤Öйú½¨ÖþµÚ¶þ¹¤³Ì¾ÖÈ¡µÃÒìÐͽ¨ÖþÓë²»¹æ
- ¡¤¡°Ò»É½ÆñÄÜÈݶþ»¢£¬¹ÚÃáÌûÊÈ«Çò²¥¡±´ò
- ¡¤¡°Ê®°Ë¹ÃÄïÒ»¶ä»¨¡±´òÒ»×î¼ÑÉúФ£¬´ÊÓï
- ¡¤¡°´º³ÇÎÞ´¦²»¿ª»¨£¬½ÄÏÃÀÅ®½¿Å®½¿¡±´ò
- ¡¤¡°ÇàɽÂÌË®¡±´òÒ»×î¼ÑÉúФ£¬´ÊÓï½âÊÍÂä
- ¡¤¡°Ð¡¼ÒÐ׶ñѵ¶ùÀÉ£¬´ó¼ÒÀñÒå½Ì×ӵܡ±´ò
- ¡¤¡°³éÏó»×÷¡±´òÒ»×î¼ÑÉúФ£¬´ÊÓï½âÊÍÂä
- ¡¤¡°ÎŹýÔòϲ¡±ÊÇʲôÉúФ£¬´ÊÓï½âÊÍÂäʵ
- ¡¤¡°ËÄÁ¬°ËÉÏϲÏà·ê£¬ÊÂʺÍ˳һ¾Å¸£¡±´ò
- ¡¤¡°¶þÈË¿ª³öÒ»Æ߸ú¡±´òÒ»ÕýÈ·ÉúФ£¬³ÉÓï
- ¡¤¡°°Ë¶·Ö®²Å¡±´òÒ»ÕýÈ·ÉúФ£¬³ÉÓï½âÊÍÂä
- ¡¤¡°ËÄÏÂÎåÉÏÊÇÁéÂ룬һÉúºÃÉ«ËûµÚÒ»¡±´ò
- ¡¤¡°Ð¡²Å´óÓá±ÊÇʲôÉúФ³ÉÓïÂäʵ
- ¡¤¡°ÄêÓ×ÎÞÖª¡±´òÒ»×î¼ÑÉúФ¶¯Î³ÉÓï½â
- ¡¤¡°¼´²»¸ûÌҲÎÞ¾ò¾®£¬²»³ÔÎå¹È³ÔÇà²Ý
- ¡¤¡°É½¹ÈÉî´¦À¼»¨Ï㡱´òÒ»×î¼ÑÉúФ¶¯Î
- ¡¤¡°Á½°¶Ô³ºïÓ뻢¶·¡±ÊÇʲôÉúФ£¬³ÉÓï½â
- ¡¤¡°Éí¾°ÙÕ½¡±´òÒ»×î¼Ñ׼ȷÉúФ¶¯Î´Ê